VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor.DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1.In the present study, the RNA interference of VEGF-A or NRP1 suppressed DJM-1 cell proliferation.Furthermore, the overexpression of the NRP1 wild type restored shNRP1-treated DJM-1 cell proliferation, whereas NRP1

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